Total synthesis and absolute configuration of nocardioazine B.
نویسندگان
چکیده
The first total synthesis of the indole alkaloid nocardioazine B was accomplished in 10 steps with an overall yield of 11.8%, establishing the absolute stereochemistry of the natural product.
منابع مشابه
Enantioselective total synthesis of (-)-lansai B and (+)-nocardioazines A and B.
The concise total syntheses of the bis(pyrroloindolines) (-)-lansai B and (+)-nocardioazines A and B are reported. The key pyrroloindoline building blocks are rapidly prepared by enantioselective formal [3+2] cycloaddition reactions. The macrocycle of (+)-nocardioazine A is constructed by an unusual intramolecular diketopiperazine formation.
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عنوان ژورنال:
- Chemical communications
دوره 48 36 شماره
صفحات -
تاریخ انتشار 2012